[Degree and duration of bronchodilatation with an agonist beta 2 administered alone versus an agonist beta 2 administered with ipratropium bromide in children with acute asthma]

Rev Alerg Mex. Jan-Feb 2000;47(1):26-9.
[Article in Spanish]


Background: The asthma is the chronic illness of the most frequent respiratory tract of the pediatric age.

Material and method: Prospective study, longitudinal, double blind, at random with 40 patient (split into two groups) with asthmatic crisis with ages of 8 to 15 years. To all was them accomplished tests of effected pulmonary function of basal way and subsequent to the inhalation of the medication. The medication were administered in two inhalations by three steps and with intervals of 10 minutes between each dose. It was considered that the treatment was effective if the improvement of the pulmonary function tests (VEF1) were presenting an increase of the 15% of their initial value.

Results: For each one of the tests accomplished in the different times were found meaningful increases in VEF1 (p < 0.05) in both groups compared with the basal and stayed meaningful until eight hours after the administration of both therapeutic plans.

Conclusion: The bronchodilator effect of the salbutamol alone and in combination with bromide of ipratropio is similar in intensity and in action time demonstrated by the VEF1.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adolescent
  • Adrenergic beta-Agonists / therapeutic use*
  • Albuterol / therapeutic use*
  • Asthma / drug therapy*
  • Bronchodilator Agents / therapeutic use*
  • Child
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Ipratropium / therapeutic use*
  • Male
  • Prospective Studies
  • Time Factors


  • Adrenergic beta-Agonists
  • Bronchodilator Agents
  • Ipratropium
  • Albuterol