Mycobacterium Tuberculosis Beijing Genotype Emerging in Vietnam

Emerg Infect Dis. May-Jun 2000;6(3):302-5. doi: 10.3201/eid0603.000312.

Abstract

To assess whether the Mycobacterium tuberculosis Beijing genotype is emerging in Vietnam, we analyzed 563 isolates from new cases by spoligotyping and examined the association between the genotype and age, resistance, and BCG vaccination status. Three hundred one (54%) patients were infected with Beijing genotype strains. The genotype was associated with younger age (and hence with active transmission) and with isoniazid and streptomycin resistance, but not with BCG vaccination.

MeSH terms

  • Adult
  • Aged
  • Antitubercular Agents / pharmacology
  • BCG Vaccine
  • Drug Resistance, Microbial
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis / classification*
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification
  • Oligodeoxyribonucleotides / genetics
  • Polymerase Chain Reaction
  • Tuberculosis / epidemiology*
  • Tuberculosis / microbiology*
  • Vaccination
  • Vietnam / epidemiology

Substances

  • Antitubercular Agents
  • BCG Vaccine
  • Oligodeoxyribonucleotides