Annular erythema of Sjögren's syndrome in a white woman

J Am Acad Dermatol. 2000 Jun;42(6):1069-72.

Abstract

Annular erythema of Sjögren's syndrome (AE-SS) is believed to be the Asian counterpart of subacute cutaneous lupus erythematosus (SCLE) in white persons. We report the second case of a white person with AE-SS, diagnosed by clinical and serologic findings, as well as the absence of histologic criteria for SCLE. The diagnosis of AE-SS was established by symptoms of xerophthalmia and xerostomia, as well as by examination of skin and salivary gland biopsy specimens. Evaluation showed the presence of anti-Ro(SS-A) and anti-La(SS-B) autoantibody, with the presence of anti-Ro(SS-A) antibody against the 60-kd, but not the 52-kd, epitope, a pattern frequently seen in both the Asians with AE-SS and in white patients with SCLE. Both skin and sicca symptoms were alleviated with combination antimalarial therapy, which included hydroxychloroquine and quinacrine. This case demonstrates that AE-SS can occur in white patients and that the autoantibody profile is similar to that described in Asians with this disease.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autoantibodies / analysis
  • Biopsy
  • Diagnosis, Differential
  • Erythema / etiology*
  • Erythema / immunology
  • European Continental Ancestry Group
  • Female
  • Humans
  • Salivary Glands / pathology
  • Sjogren's Syndrome / complications*
  • Skin / pathology

Substances

  • Autoantibodies