Abnormal blood flow and red blood cell deformability in severe malaria

Parasitol Today. 2000 Jun;16(6):228-32. doi: 10.1016/s0169-4758(00)01666-5.


Obstruction of the microcirculation plays a central role in the pathophysiology of severe malaria. Here, Arjen Dondorp and colleagues describe the various contributors to impaired microcirculatory flow in falciparum malaria: sequestration, rosetting and recent findings regarding impaired red blood cell deformability. The correlation with clinical findings and possible therapeutic consequences are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Animals
  • Blood Flow Velocity
  • Child
  • Erythrocyte Deformability*
  • Hemorheology
  • Humans
  • Malaria, Falciparum / blood
  • Malaria, Falciparum / physiopathology*
  • Microcirculation
  • Plasmodium falciparum / pathogenicity