Partners and pathwaysrepairing a double-strand break

Trends Genet. 2000 Jun;16(6):259-64. doi: 10.1016/s0168-9525(00)02022-9.


Double-strand chromosome breaks can arise in a number of ways, by ionizing radiation, by spontaneous chromosome breaks during DNA replication, or by the programmed action of endonucleases, such as in meiosis. Broken chromosomes can be repaired either by one of several homologous recombination mechanisms, or by a number of nonhomologous repair processes. Many of these pathways compete actively for the repair of a double-strand break. Which of these repair pathways is used appears to be regulated developmentally, genetically and during the cell cycle.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alleles
  • Animals
  • Chromatids
  • DNA Damage / genetics
  • DNA Repair / physiology*
  • DNA Replication
  • DNA*
  • DNA, Single-Stranded
  • Gene Expression Regulation
  • Meiosis
  • Mitosis
  • Recombination, Genetic*


  • DNA, Single-Stranded
  • DNA