Frey syndrome treatment with botulinum toxin

Otolaryngol Head Neck Surg. 2000 Jun;122(6):821-7. doi: 10.1016/S0194-59980070008-8.


The goal of this work is to present our results of the intradermic infiltration with botulinum toxin in patients with Frey syndrome. Sixteen hemifaces in 15 patients were studied. Gustatory stimulation was evoked by sucking on a slice of lemon while measurements were done on both hemifaces, with the normal side being used as a control. Skin temperature and color (erythema) were measured with a digital surface thermometer and a skin chromameter, respectively. Sweat quantity and surface were measured by using the previously described blotting paper and iodine-sublimated paper histogram methods, respectively. Testing was repeated 2 weeks after skin infiltration with botulinum toxin (dilution of 50 U/mL). The interinjection distances were 1 cm, and 0.1 mL (5 U) was infiltrated at each injection site. Frey syndrome complaints disappeared in all patients. Small residual amounts of sweat were measurable. The difference in sweat quantity before and after botulinum toxin infiltration was significant in every patient (P < 0.001). Skin temperature and color measurement gave inconclusive results. In conclusion, Frey syndrome treatment with botulinum toxin is an efficient and well-tolerated technique. Further work should address the optimal injection parameters.

MeSH terms

  • Botulinum Toxins / administration & dosage
  • Botulinum Toxins / therapeutic use*
  • Cholinergic Agents / administration & dosage
  • Cholinergic Agents / therapeutic use*
  • Humans
  • Sweating, Gustatory / drug therapy*


  • Cholinergic Agents
  • Botulinum Toxins