Pathogens resistant to antimicrobial agents. Epidemiology, molecular mechanisms, and clinical management

Infect Dis Clin North Am. 2000 Jun;14(2):293-319. doi: 10.1016/s0891-5520(05)70249-x.


The emergence of resistance to antimicrobial agents continues to be a major problem in the nosocomial setting and now in nursing homes and the community as well. Bacteria use a variety of strategies to avoid the inhibitory effects of antibiotic agents and have evolved highly efficient means for the dissemination of resistance traits. Control of antibiotic-resistant pathogens provides a major challenge for both the medical community and society in general. To control the emergence of resistant pathogens, CDC and infection control guidelines must be adhered to, and antibiotics must be used more judiciously.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteria / drug effects*
  • Bacteria / genetics
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / epidemiology
  • Bacterial Infections / microbiology*
  • Drug Resistance, Microbial / genetics*
  • Drug Resistance, Multiple / genetics
  • Humans
  • Molecular Epidemiology


  • Anti-Bacterial Agents