Antibiotics for gram-positive bacterial infections. Vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid

Infect Dis Clin North Am. 2000 Jun;14(2):463-74. doi: 10.1016/s0891-5520(05)70258-0.

Abstract

Vancomycin is a safe, effective antibiotic for a variety of serious gram-positive infections. Because of emerging resistance in enterococci and staphylococci and the emerging threat of spread of vancomycin-resistant genes to other gram-positive organisms, judicious use of vancomycin should be promoted. Quinupristin/dalfopristin, a streptogramin antibiotic, and linezolid, an oxazolidinone, show promise against some strains of gram-positive bacteria that are resistant to vancomycin.

Publication types

  • Review

MeSH terms

  • Acetamides / pharmacokinetics
  • Acetamides / pharmacology
  • Acetamides / therapeutic use*
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Resistance, Microbial
  • Gram-Positive Bacteria / drug effects
  • Gram-Positive Bacterial Infections / drug therapy*
  • Humans
  • Linezolid
  • Oxazoles / pharmacokinetics
  • Oxazoles / pharmacology
  • Oxazoles / therapeutic use*
  • Oxazolidinones*
  • Teicoplanin / pharmacokinetics
  • Teicoplanin / pharmacology
  • Teicoplanin / therapeutic use
  • Vancomycin / pharmacokinetics
  • Vancomycin / pharmacology
  • Vancomycin / therapeutic use
  • Virginiamycin / analogs & derivatives
  • Virginiamycin / pharmacokinetics
  • Virginiamycin / pharmacology
  • Virginiamycin / therapeutic use

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazoles
  • Oxazolidinones
  • Virginiamycin
  • quinupristin
  • Teicoplanin
  • Vancomycin
  • Linezolid
  • dalfopristin