Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection

Intern Med. 2000 May;39(5):397-400. doi: 10.2169/internalmedicine.39.397.


Type II cryoglobulinemia is sometimes observed in patients with HCV infection. It is also well known that some cases with membranoproliferative glomerulonephritis (MPGN) possess cryoglobulinemia, which can induce neuropathy. We treated a 73-year-old woman with hepatitis C virus (HCV) who was admitted to our department because of proteinuria. She was diagnosed as MPGN according to renal biopsy. Her ankle jerk was absent with reduced touch sensation and vibration below the knees; sural nerve biopsy revealed demyelinating neuropathy. Administration of prednisolone resulted in improved proteinuria. Cryoglobulinemia associated with HCV infection seemed to induce MPGN and demyelinating neuropathy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Inflammatory Agents / therapeutic use
  • Cryoglobulinemia / classification
  • Cryoglobulinemia / complications*
  • Cryoglobulinemia / etiology
  • Demyelinating Diseases / diagnosis
  • Demyelinating Diseases / drug therapy
  • Demyelinating Diseases / etiology*
  • Female
  • Glomerulonephritis, Membranoproliferative / diagnosis
  • Glomerulonephritis, Membranoproliferative / drug therapy
  • Glomerulonephritis, Membranoproliferative / etiology*
  • Hepatitis C / complications*
  • Humans
  • Prednisolone / therapeutic use


  • Anti-Inflammatory Agents
  • Prednisolone