Steroid 5alpha-reductase inhibitory activity and hair regrowth effects of an extract from Boehmeria nipononivea

Biosci Biotechnol Biochem. 2000 Apr;64(4):875-7. doi: 10.1271/bbb.64.875.


The acetone extract of Boehmeria nipononivea showed both potent 5alpha-reductase inhibitory activity and hair regrowth promotion effects on mice. 5alpha-Reductase inhibitory activity-guided fractionation led to six active fatty acids: alpha-linolenic, linoleic, palmitic, elaidic, oleic and stearic acids. The extract of B. nipononivea, and alphalinolenic, elaidic and stearic acids exhibited a hair regrowth effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-alpha Reductase Inhibitors*
  • Acetone
  • Alopecia / drug therapy*
  • Animals
  • Enzyme Inhibitors / pharmacology
  • Fatty Acids / therapeutic use*
  • Hair / growth & development*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Plant Extracts / pharmacology*
  • Rosales / chemistry*


  • 5-alpha Reductase Inhibitors
  • Enzyme Inhibitors
  • Fatty Acids
  • Plant Extracts
  • Acetone