Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus

I A Parshikov; J P Freeman; J O Lay Jr; R D Beger; A J Williams; J B Sutherland

doi:10.1128/AEM.66.6.2664-2667.2000

Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus

Appl Environ Microbiol. 2000 Jun;66(6):2664-7. doi: 10.1128/AEM.66.6.2664-2667.2000.

Authors

I A Parshikov¹, J P Freeman, J O Lay Jr, R D Beger, A J Williams, J B Sutherland

Affiliation

¹ Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.

Abstract

Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N-oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / metabolism*
Biotransformation
Chromatography, High Pressure Liquid
Enrofloxacin
Fluoroquinolones*
Magnetic Resonance Spectroscopy
Mucor / growth & development
Mucor / metabolism*
Quinolones / chemistry
Quinolones / metabolism*

Substances

Anti-Infective Agents
Fluoroquinolones
Quinolones
Enrofloxacin