Evidence for novel non-angiogenic pathway in breast-cancer metastasis. Breast Cancer Progression Working Party

Lancet. 2000 May 20;355(9217):1787-8.


We have reported that angiogenic primary breast carcinoma can relapse not only as angiogenic, but also as non-angiogenic, lung metastases. This non-angiogenic pathway seems to be a novel pathway of cancer progression, and such tumours are likely to be resistant to antiangogenic treatment.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / pathology*
  • Humans
  • Lung Neoplasms / blood supply*
  • Lung Neoplasms / secondary*
  • Lymphatic Metastasis
  • Neovascularization, Pathologic