Decreased tear secretion after laser in situ keratomileusis for high myopia

J Refract Surg. May-Jun 2000;16(3):362-4.


Purpose: To investigate the changes in tear secretion and tear film stability after excimer laser in situ keratomileusis (LASIK) for high myopia.

Methods: One eye of 28 patients underwent unilateral LASIK for the correction of myopia with spherical equivalent refractions ranging from -6.37 to -18.25 D (mean, -11.98 +/- 3.45 D). Schirmer tear test values without anesthesia at 5 minutes and tear break-up time values were measured 4 weeks after LASIK. Unoperated contralateral eyes were used as a control for each patient. The Schirmer tear test and tear break-up time values were analyzed statistically using the independent t-test.

Results: The mean Schirmer tear test value was 16.17 +/- 2.50 mm in the operated eyes and 21.07 +/- 7.03 mm in the unoperated (control) eyes of the same patients (P = .001). The mean tear break-up time value was 21.0 +/- 3.55 seconds in the operated eyes and 21.27 +/- 6.79 seconds in the control eyes (P = .85).

Conclusion: Tear secretion decreased following LASIK probably due to decrease in corneal sensitivity, but tear film stability appeared unaltered.

MeSH terms

  • Adult
  • Cornea / metabolism
  • Cornea / surgery*
  • Diagnostic Techniques, Ophthalmological
  • Female
  • Humans
  • Keratomileusis, Laser In Situ*
  • Male
  • Myopia / metabolism
  • Myopia / surgery*
  • Tears / chemistry
  • Tears / metabolism*