Endovascular treatment of intracranial aneurysms with Guglielmi Detachable Coils: emphasis on new techniques

J Clin Neurosci. 2000 May;7(3):244-53. doi: 10.1054/jocn.1999.0211.


Endovascular therapy for intracranial aneurysms has evolved since Serbinenko pioneered embolisation with latex balloons in the 1970s. The focus of modern endovascular therapy has shifted to the use of Guglielmi Detachable Coils (GDC; Boston Scientific Corporation, Natick, MA, USA) which are retrievable until the operator is satisfied with placement and they are detached. GDC therapy has been shown to be most efficacious in smaller aneurysms with relatively large dome:neck ratios which allow maximal coil packing within the aneurysm lumen. Wide neck aneurysms with dome:neck ratios of less than 2.0 and large aneurysms have a significantly lower incidence of complete treatment, with higher rates of repeat rupture following GDC therapy. The geometry of wide neck aneurysms is less favourable for retention of coils within the aneurysm lumen, resulting in greater risk of parent vessel compromise from coil herniation and difficulty obtaining maximal coil packing. This chapter will summarise GDC therapy for intracranial aneurysms including newer techniques designed to address the problem of wide neck aneurysms.

Publication types

  • Review

MeSH terms

  • Angioplasty, Balloon / adverse effects
  • Angioplasty, Balloon / methods*
  • Cerebral Angiography
  • Embolization, Therapeutic / adverse effects
  • Embolization, Therapeutic / instrumentation*
  • Embolization, Therapeutic / methods*
  • Humans
  • Intracranial Aneurysm / diagnostic imaging
  • Intracranial Aneurysm / pathology
  • Intracranial Aneurysm / therapy*
  • Patient Selection
  • Stents