Forty-three parturients with severe late gestosis were subjected to cesarean section under endotracheal general anesthesia (EGA) (23 pts) and combined epidural anesthesia (CEA) (20 pts). Lipid peroxidation (LPO), antioxidant system (AOS), and lipid metabolism parameters were evaluated at various stages of anesthesia and operation. EN involved a marked increase in LPO, suppressed the activities of vitamin and enzymatic components of AOS, and disturbed lipid metabolism, while CEA was associated with a less pronounced intensification of LPO, slight suppression of AOS, and slight changes in lipid metabolism, which makes this types of analgesia preferable.