The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

Nat Med. 2000 Jun;6(6):637-41. doi: 10.1038/76211.


The role of the 3' untranslated region in posttranscriptional regulation of mRNA expression is being elucidated. Here we describe diseases arising from anomalies in this region, that affect the expression of one or more genes.

Publication types

  • Review

MeSH terms

  • 3' Untranslated Regions / physiology*
  • Animals
  • Humans
  • Myotonic Dystrophy / genetics
  • Protein Biosynthesis
  • RNA Processing, Post-Transcriptional*
  • RNA Stability


  • 3' Untranslated Regions