Modelling of congenital nystagmus waveforms produced by saccadic system abnormalities

Biol Cybern. 2000 May;82(5):391-9. doi: 10.1007/s004220050593.


Models of the mechanisms of normal eye movements are typically described in terms of the block diagrams which are used in control theory. An alternative approach to understanding the mechanisms of normal eye movements involves describing the eye movement behaviour in terms of smooth changes in state variables. The latter approach captures the burst cell firing against motor error (difference between target gaze angle and current gaze angle) phase plane behaviour which is found experimentally and facilitates the modelling of variations in burst cell behaviour. A novel explanation of several types of congenital nystagmus waveforms is given in terms of a saccadic termination abnormality.

MeSH terms

  • Humans
  • Models, Neurological*
  • Nonlinear Dynamics
  • Nystagmus, Pathologic / congenital
  • Nystagmus, Pathologic / physiopathology*
  • Saccades / physiology*