Abstract
Notch signalling is best known for its role in lateral inhibition, where it acts to prevent differentiation of cells neighbouring one that has 'won out' in a competition to differentiate. Recent results suggest that Notch signalling can work in the opposite way, and promote differentiation of the receiving cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation
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Humans
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Intracellular Signaling Peptides and Proteins
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Keratinocytes / cytology
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Keratinocytes / physiology*
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Membrane Proteins / physiology*
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Receptors, Cell Surface / physiology
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Receptors, Notch
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Signal Transduction*
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Skin / cytology*
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Skin Physiological Phenomena*
Substances
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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Receptors, Cell Surface
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Receptors, Notch
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delta protein