Protein sorting: recognizing mitochondrial presequences

Curr Biol. 2000 Jun 1;10(11):R412-5. doi: 10.1016/s0960-9822(00)00507-8.

Abstract

The mitochondrial protein import machinery specifically recognizes many different preproteins lacking a consensus sequence. The three-dimensional structure of an import receptor complexed to an amino-terminal targeting 'presequence' provides exciting insight into the molecular mechanism of signal recognition.

Publication types

  • Review

MeSH terms

  • Aldehyde Dehydrogenase / chemistry
  • Aldehyde Dehydrogenase / metabolism
  • Amino Acid Sequence
  • Animals
  • Intracellular Membranes / physiology*
  • Intracellular Membranes / ultrastructure
  • Mitochondria / physiology*
  • Mitochondria / ultrastructure
  • Models, Biological
  • Protein Conformation
  • Protein Precursors / chemistry
  • Protein Precursors / metabolism*
  • Protein Processing, Post-Translational*

Substances

  • Protein Precursors
  • Aldehyde Dehydrogenase