Regulation of sulfate transport and synthesis of sulfur-containing amino acids

Curr Opin Plant Biol. 2000 Jun;3(3):188-95.

Abstract

Recent research indicates that several sulfate transporters - exhibiting different tissue specificities and modes of expression - may play distinct roles in sulfate uptake within specific tissues and in long-distance sulfate translocation. The transcription levels of particular genes and feedback inhibition of serine acetyltransferase play major roles in regulating sulfur assimilation and cysteine synthesis. O-acetylserine and glutathione presumably act within the cysteine synthesis pathway as derepressor and repressor, respectively. A unique autoregulatory mechanism that stabilizes mRNA levels has recently been proposed for the regulation of methionine synthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cysteine / biosynthesis*
  • Gene Expression Regulation, Plant
  • Membrane Transport Proteins*
  • Methionine / biosynthesis*
  • Models, Biological
  • Serine / analogs & derivatives
  • Serine / physiology
  • Signal Transduction
  • Sulfate Transporters
  • Sulfates / metabolism*

Substances

  • Carrier Proteins
  • Membrane Transport Proteins
  • SLC26A4 protein, human
  • Sulfate Transporters
  • Sulfates
  • Serine
  • Methionine
  • O-acetylserine
  • Cysteine