Retrospective screening for heterogeneous vancomycin resistance in diverse Staphylococcus aureus clones disseminated in French hospitals

J Antimicrob Chemother. 2000 Jun;45(6):887-90. doi: 10.1093/jac/45.6.887.


Twenty-five different Staphylococcus aureus strains that are widespread in France were screened by various methods for heterogeneous and low-level resistance to vancomycin. Population analysis on brain-heart infusion agar containing 4 mg/L of the drug detected resistant cells at frequencies of 10-7 to 10-6 in five multiply resistant strains. There was no antagonism between vancomycin and beta-lactam antibiotics. One of the five strains, isolated in 1993, was considered a putative progenitor of a French nosocomial S. aureus strain isolated in 1998 and for which the vancomycin MIC was 8 mg/L.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cross Infection / microbiology
  • Culture Media
  • Drug Resistance, Microbial
  • France / epidemiology
  • Humans
  • Microbial Sensitivity Tests
  • Retrospective Studies
  • Staphylococcal Infections / epidemiology
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Vancomycin / pharmacology*


  • Anti-Bacterial Agents
  • Culture Media
  • Vancomycin