Antimicrobial Resistance in Enterobacteriaceae in Brooklyn, NY: Epidemiology and Relation to Antibiotic Usage Patterns

J Antimicrob Chemother. 2000 Jun;45(6):895-8. doi: 10.1093/jac/45.6.895.

Abstract

In November 1997, all Enterobacteriaceae isolated at 15 hospitals in Brooklyn were collected. Extended-spectrum beta-lactamases (ESBLs) were present in 44% of 409 Klebsiella pneumoniae isolates. Six isolates had reduced susceptibility to carbapenems, including two that were not susceptible to any of the antibiotics tested. Pulsed field gel electrophoresis revealed a commonality of resistant isolates within and between hospitals. The occurrence of ESBLcontaining isolates was associated with cephalosporin usage (P = 0.055). ESBLs were present in 4.7% of Escherichia coli and 9.5% of Proteus mirabilis isolates. It is concluded that ESBL-producing Enterobacteriaceae are endemic in Brooklyn, are spread between hospitals, and may be associated with cephalosporin usage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Drug Resistance, Microbial
  • Drug Utilization
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae Infections / epidemiology*
  • Enterobacteriaceae Infections / microbiology*
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Humans
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology
  • Microbial Sensitivity Tests
  • New York City / epidemiology
  • Proteus mirabilis / drug effects
  • Proteus mirabilis / enzymology
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases