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. 2000 Jun;70(3):323-7.
doi: 10.1016/s0378-8741(99)00168-3.

Antinociceptive Effect of the Essential Oil From Cymbopogon Citratus in Mice

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Antinociceptive Effect of the Essential Oil From Cymbopogon Citratus in Mice

G S Viana et al. J Ethnopharmacol. .

Abstract

The essential oil (EO) from leaves of Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25-100 mg/kg) administration. EO (50-200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, EO (50 and 200 mg/kg, i.p.) inhibited preferentially the second phase of the response, causing inhibitions of 100 and 48% at 200 mg/kg, i.p. and 100 mg/kg, p.o., respectively. On the other hand, the opioid antagonist naloxone blocked the central antinociceptive effect of EO, suggesting that EO acts both at peripheral and central levels.

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