Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

Trends Biochem Sci. 2000 Jun;25(6):277-83. doi: 10.1016/s0968-0004(00)01596-6.


A novel multiprotein complex has recently been identified as a coactivator for transcriptional control of protein-encoding genes by RNA polymerase II in higher eukaryotic cells. This complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its structural and functional characteristics, promises to be a key target of diverse regulatory circuits.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Enzymologic*
  • Humans
  • Invertebrates / genetics*
  • Models, Biological
  • Peptides / chemistry
  • RNA Polymerase II / genetics*
  • Transcription, Genetic*
  • Transcriptional Activation*
  • Yeasts / genetics*


  • Peptides
  • RNA Polymerase II