LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors

Trends Biochem Sci. 2000 Jun;25(6):284-9. doi: 10.1016/s0968-0004(00)01583-8.


A number of unusual seven-transmembrane molecules have recently been characterized that have significant amino acid sequence similarity within the membrane-spanning hydrophobic regions and intervening loops to members of G-protein-coupled receptor family B. However, in contrast to the family-B G-protein-coupled receptors, these molecules have unusually large N-terminal extracellular domains that contain a number of well- characterized protein modules. The range of cell types expressing these complex molecules and their potential roles in cell adhesion and signalling have become a major focus of research in a number of biological systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion
  • Cell Membrane / chemistry*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Rats
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / classification
  • Sequence Homology, Amino Acid
  • Signal Transduction


  • Receptors, Cell Surface

Associated data

  • GENBANK/AA198691
  • GENBANK/AC004262
  • GENBANK/D87469
  • GENBANK/T10363
  • GENBANK/W03697
  • GENBANK/Z54306