The bactericidal action of penicillin: new clues to an unsolved mystery

Trends Microbiol. 2000 Jun;8(6):274-8. doi: 10.1016/s0966-842x(00)01762-5.

Abstract

The Staphylococcus aureus lrgAB operon was recently shown to inhibit extracellular murein hydrolase activity and increase tolerance to penicillin. Further characterization of this operon could provide novel insight into the dynamics of S. aureus cell wall metabolism and the mechanism of penicillin-induced lethality.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / metabolism
  • Cell Wall / drug effects
  • Cell Wall / metabolism
  • Gene Expression Regulation / drug effects*
  • Gene Expression Regulation, Enzymologic / drug effects
  • Membrane Proteins*
  • Mutation
  • N-Acetylmuramoyl-L-alanine Amidase / genetics
  • N-Acetylmuramoyl-L-alanine Amidase / metabolism
  • Operon
  • Penicillins / pharmacology*
  • Signal Transduction
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics

Substances

  • Bacterial Proteins
  • LrgA protein, Staphylococcus aureus
  • Membrane Proteins
  • Penicillins
  • N-Acetylmuramoyl-L-alanine Amidase