Fluvastatin Increases Prostacyclin and Decreases Endothelin Production by Human Umbilical Vein Endothelial Cells

Int J Clin Pharmacol Ther. 2000 May;38(5):270-2. doi: 10.5414/cpp38270.

Abstract

Fluvastatin, an agent of a class of lipid-lowering drugs, the "statins", significantly enhanced prostacyclin synthesis at the concentrations of 0.1 microM and 1 microM and significantly reduced endothelin production at the concentrations 0.01, 0.1 and 1 microM in cell cultures of human umbilical endothelial veins. Since prostacyclin is a vasodilator and endothelin a vasoconstrictor, fluvastatin may have a significant effect on hemodynamics by favoring the balance towards vasodilation. This mechanism may contribute to the prevention of cardiovascular diseases.

MeSH terms

  • Anticholesteremic Agents / pharmacology*
  • Endothelins / biosynthesis*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism*
  • Epoprostenol / biosynthesis*
  • Fatty Acids, Monounsaturated / pharmacology*
  • Female
  • Fluvastatin
  • Humans
  • In Vitro Techniques
  • Indoles / pharmacology*
  • Umbilical Veins / cytology
  • Umbilical Veins / drug effects
  • Umbilical Veins / metabolism

Substances

  • Anticholesteremic Agents
  • Endothelins
  • Fatty Acids, Monounsaturated
  • Indoles
  • Fluvastatin
  • Epoprostenol