Chlamydia pneumoniae and cardiovascular disease: an evolutionary perspective on infectious causation and antibiotic treatment

J Infect Dis. 2000 Jun;181 Suppl 3:S394-401. doi: 10.1086/315602.


Evolutionary considerations implicate infectious causation of atherosclerosis and help to resolve different risk factors as parts of an overall process of disease causation. An evolutionary approach also provides insight for the timing of research efforts to provide better control of pathogen evolution. In particular, evolutionary considerations emphasize the need to understand the transmissibility of Chlamydia pneumoniae from systemic infections in order to control the evolution of antibiotic resistance.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Arteriosclerosis / etiology*
  • Arteriosclerosis / microbiology
  • Chlamydia Infections / complications*
  • Chlamydia Infections / drug therapy
  • Chlamydia Infections / microbiology
  • Chlamydophila pneumoniae / drug effects
  • Chlamydophila pneumoniae / genetics*
  • Drug Resistance, Microbial
  • Evolution, Molecular
  • Genetic Predisposition to Disease
  • Humans


  • Anti-Bacterial Agents