Expression of the interferon-gamma-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions

Neuropathol Appl Neurobiol. 2000 Apr;26(2):133-42. doi: 10.1046/j.1365-2990.2000.026002133.x.


The recruitment of leucocytes to sites of inflammation is an important feature of multiple sclerosis (MS) pathology. Chemokines are involved in the activation and specific directional migration of monocytes and T-lymphocytes to sites of inflammation. Using immunocytochemistry, the expression of the alpha-chemokines, interferon (IFN)-gamma-inducible protein-10 (IP-10) and monokine induced by IFN-gamma (Mig), and their receptor CXCR3 have been examined in post-mortem central nervous system (CNS) tissue from MS cases at different stages of lesion development. In actively demyelinating lesions both IP-10 and Mig protein were predominantly expressed by macrophages within the plaque and by reactive astrocytes in the surrounding parenchyma. CXCR3 was expressed by T cells and by astrocytes within the plaque. Interferon-gamma may stimulate glial cells to express IP-10 and Mig, which continue the local inflammatory response by selectively recruiting activated T-lymphocytes into the CNS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibody Specificity
  • Central Nervous System / chemistry
  • Central Nervous System / immunology
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Chemokines, CXC / analysis
  • Chemokines, CXC / genetics
  • Chemokines, CXC / immunology*
  • Chemokines, CXC / metabolism
  • Demyelinating Diseases / immunology
  • Female
  • Gene Expression / immunology
  • Humans
  • In Situ Hybridization
  • Intercellular Signaling Peptides and Proteins*
  • Interferon-gamma / analysis
  • Interferon-gamma / genetics
  • Interferon-gamma / immunology*
  • Male
  • Middle Aged
  • Multiple Sclerosis / immunology*
  • RNA, Messenger / analysis
  • Receptors, CXCR3
  • Receptors, Chemokine / analysis
  • Receptors, Chemokine / genetics
  • Receptors, Chemokine / immunology*
  • T-Lymphocytes / immunology


  • CXCL9 protein, human
  • CXCR3 protein, human
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Chemokines, CXC
  • Intercellular Signaling Peptides and Proteins
  • RNA, Messenger
  • Receptors, CXCR3
  • Receptors, Chemokine
  • Interferon-gamma