The role of prostaglandins in penile erection

Prostaglandins Leukot Essent Fatty Acids. 2000 Mar;62(3):137-46. doi: 10.1054/plef.2000.0133.


The balance of penile smooth muscle tone is finely controlled, with contractile factors acting in opposition to relaxant factors. The principal agents in this process are undoubtedly noradrenaline and nitric oxide. Prostaglandins probably have a crucial role in the 'fine tuning' of corporal smooth muscle tone. Their effects on control mechanisms in the healthy penis are more likely to be modulatory rather than direct.

Publication types

  • Review

MeSH terms

  • Endothelium / physiology
  • Humans
  • Male
  • Neurotransmitter Agents / physiology
  • Penile Erection / physiology*
  • Penis / anatomy & histology
  • Penis / blood supply
  • Penis / innervation
  • Prostaglandins / chemistry
  • Prostaglandins / metabolism
  • Prostaglandins / physiology*


  • Neurotransmitter Agents
  • Prostaglandins