XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development

Mech Dev. 2000 Jun;94(1-2):189-93. doi: 10.1016/s0925-4773(00)00318-x.


We have isolated a Xenopus homologue of the zinc finger/homeodomain-containing transcriptional repressor Smad-interacting protein-1 (SIP1) from mouse. XSIP1 is activated at the early gastrula stage and transcription occurs throughout embryogenesis. At the beginning of gastrulation, XSIP1 is strongly expressed in prospective neurectoderm. At the neurula stage, XSIP1 is highly expressed within the neural plate but weakly in the dorsal midline. At later stages of development transcripts are detected primarily within the neural tube and neural crest. In the adult, XSIP1 expression is detected at variable levels in several organs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Embryo, Nonmammalian
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism*
  • Molecular Sequence Data
  • Nervous System / embryology*
  • Proteins / genetics
  • Proteins / metabolism
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism*
  • Sequence Homology, Amino Acid
  • Smad Proteins
  • Smad2 Protein
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Xenopus / embryology
  • Xenopus / genetics*
  • Xenopus Proteins*
  • Zinc Fingers


  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Proteins
  • Repressor Proteins
  • Smad Proteins
  • Smad2 Protein
  • Smad2 protein, Xenopus
  • Trans-Activators
  • Xenopus Proteins
  • ZEB2 protein, Xenopus

Associated data

  • GENBANK/AF237679