IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection

Immunity. 2000 May;12(5):483-94. doi: 10.1016/s1074-7613(00)80200-9.

Abstract

The generation of an adaptive immune response against intracellular pathogens requires the recruitment of effector T cells to sites of infection. Here we show that the chemokine IP-10, a specific chemoattractant for activated T cells, controls this process in mice naturally infected with Toxoplasma gondii. Neutralization of IP-10 in infected mice inhibited the massive influx of T cells into tissues and impaired antigen-specific T cell effector functions. This resulted in >1000-fold increase in tissue parasite burden and a marked increase in mortality compared to control antibody-treated mice. These observations suggest that IP-10 may play a broader role in the localization and function of effector T cells at sites of Th1 inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Movement / immunology
  • Chemokine CXCL10
  • Chemokines, CXC / immunology*
  • Chemotactic Factors / immunology
  • Immunity, Innate
  • Mice
  • Mice, Inbred C57BL
  • T-Lymphocytes / immunology*
  • Toxoplasma / immunology*
  • Toxoplasmosis, Animal / immunology*

Substances

  • Chemokine CXCL10
  • Chemokines, CXC
  • Chemotactic Factors