Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species

L M West; P T Northcote; K A Hood; J H Miller; M J Page

doi:10.1021/np9904511

Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species

J Nat Prod. 2000 May;63(5):707-9. doi: 10.1021/np9904511.

Authors

L M West¹, P T Northcote, K A Hood, J H Miller, M J Page

Affiliation

¹ School of Chemical and Physical Sciences, Victoria University of Wellington, New Zealand.

PMID: 10843597
DOI: 10.1021/np9904511

Abstract

A new mycalamide, mycalamide D (3), has been isolated from the New Zealand marine sponge Mycale sp. This new metabolite, in which the C13-O-methyl group of mycalamide A (1) is replaced by a hydrogen atom, was found to be cytotoxic to a range of mammalian cell lines, with a potency approximately 20-fold less than that of 1.

MeSH terms

Animals
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
LLC-PK1 Cells
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Conformation
New Zealand
Porifera / chemistry*
Pyrans / isolation & purification*
Pyrans / pharmacology
Spectrophotometry, Ultraviolet
Stereoisomerism
Swine
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Pyrans
mycalamide D