Combined effect of polytetrafluoroethylene and 5-fluorouracil on delayed adjustable strabismus surgery

J Pediatr Ophthalmol Strabismus. May-Jun 2000;37(3):163-7.

Abstract

Purpose: To determine a more reliable method for performing delayed suture adjustment to prevent the formation of postoperative adhesions and delay the time of adjustment.

Methods: Thirty-two rabbit eyes were divided into three groups. After recession of the superior rectus muscle, 5-fluorouracil (5-FU) was administered beneath and over the superior rectus muscle in group 5-FU (12 eyes); polytetrafluoroethylene (PTFE) and 5-FU were administered in group P-f (10 eyes); and PTFE, 5-FU, and Viscoat (chondroitin sulfate, sodium hyaluronate, Alcon Laboratories Inc, Fort Worth, Tex) were administered in group P-fv (10 eyes). Delayed adjustment was performed once on each superior rectus muscle at 1, 2, and 3 weeks postoperatively in group 5-FU and at 2 and 4 weeks postoperatively in groups P-f and P-fv. The length and force for the adjustment and the degree of adhesions were recorded.

Results: The use of fluorouracil allowed adjustment to be delayed up to 1 week after surgery in three of four eyes. The combined use of PTFE and 5-FU or addition of Viscoat allowed adjustment to be delayed for up to 4 weeks after surgery in four of five eyes.

Conclusion: The combined use of PTFE, 5-FU and Viscoat is useful for delaying suture adjustment in rabbit eyes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimetabolites / administration & dosage*
  • Chondroitin / administration & dosage
  • Chondroitin Sulfates
  • Combined Modality Therapy
  • Drug Combinations
  • Fluorouracil / administration & dosage*
  • Hyaluronic Acid / administration & dosage
  • Oculomotor Muscles / surgery*
  • Polytetrafluoroethylene*
  • Postoperative Complications / prevention & control
  • Rabbits
  • Strabismus / surgery*
  • Suture Techniques*
  • Tissue Adhesions / prevention & control

Substances

  • Antimetabolites
  • Drug Combinations
  • chondroitin sulfate, sodium hyaluronate drug combination
  • Polytetrafluoroethylene
  • Hyaluronic Acid
  • Chondroitin
  • Chondroitin Sulfates
  • Fluorouracil