Mi-Transcription Factor as a Regulator of Mast Cell Differentiation

Int J Hematol. 2000 Apr;71(3):197-202.

Abstract

Masts cells are progeny of the hematopoietic stem cell. For the differentiation of mast cells, a transcription factor encoded by the mouse mi locus (MITF) plays an important role. The expression of many genes encoding proteins that are essential for the function of mast cells is regulated by MITF. Because various mutant mice are available at the mi locus and because cultured mast cells are easily obtained from the spleen of these mutant mice, this system may be a good model for studying the regulation of hematopoietic cell differentiation by a transcription factor.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics*
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation*
  • Mast Cells / cytology
  • Mast Cells / physiology*
  • Mice
  • Mice, Mutant Strains
  • Microphthalmia-Associated Transcription Factor
  • Transcription Factors / genetics

Substances

  • DNA-Binding Proteins
  • Microphthalmia-Associated Transcription Factor
  • Mitf protein, mouse
  • Transcription Factors