Altered lymphocyte reactivity in rheumatoid arthritis

Arthritis Rheum. May-Jun 1976;19(3):509-15. doi: 10.1002/art.1780190301.


Blastogenic transformation of peripheral lymphocytes with phytohemagglutinin (PHA), conconavalin A (Con A), and pokeweed mitogen (PWM) was studied in 29 patients with rheumatoid arthritis (RA). The PHA response was depressed in a subgroup of RA patients with erosive disease. The Con A response was also depressed and paralleled the PHA response. The PWM response was not depressed. These results lend support to the hypothesis of a functional defect of cellular immunity in RA. It was shown that lymphocyte responsiveness to a single mitogen concentration is not an adequate assessment of the overall responsiveness of the lymphocytes tested.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Antinuclear / analysis
  • Arthritis, Rheumatoid / immunology*
  • Concanavalin A / pharmacology
  • Dose-Response Relationship, Drug
  • Humans
  • Lectins / pharmacology
  • Lymphocyte Activation* / drug effects
  • Lymphocytes / drug effects
  • Lymphocytes / immunology*
  • Middle Aged
  • Regression Analysis
  • Tuberculosis / immunology


  • Antibodies, Antinuclear
  • Lectins
  • Concanavalin A