FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis

Cell. 2000 Apr 28;101(3):331-40. doi: 10.1016/s0092-8674(00)80842-9.


Plant reproduction requires precise control of flowering in response to environmental cues. We isolated a late-flowering Arabidopsis mutant, fkf1, that is rescued by vemalization or gibberellin treatment. We positionally cloned FKF1, which encodes a novel protein with a PAS domain similar to the flavin-binding region of certain photoreceptors, an F box characteristic of proteins that direct ubiquitin-mediated degradation, and six kelch repeats predicted to fold into a beta propeller. FKF1 mRNA levels oscillate with a circadian rhythm, and deletion of FKF1 alters the waveform of rhythmic expression of two clock-controlled genes, implicating FKF1 in modulating the Arabidopsis circadian clock.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / genetics
  • Arabidopsis / physiology
  • Arabidopsis Proteins*
  • Base Sequence
  • Biological Clocks / physiology*
  • Circadian Rhythm
  • DNA, Plant
  • Genes, Plant
  • Hypocotyl
  • Light
  • Molecular Sequence Data
  • Plant Proteins / genetics
  • Plant Proteins / physiology*
  • RNA, Messenger


  • Arabidopsis Proteins
  • DNA, Plant
  • FKF1 protein, Arabidopsis
  • Plant Proteins
  • RNA, Messenger

Associated data

  • GENBANK/AF216523
  • GENBANK/AF216525