Pseudoscleroderma associated with lung cancer: correlation of collagen type I and connective tissue growth factor gene expression

Br J Dermatol. 2000 Jun;142(6):1228-33. doi: 10.1046/j.1365-2133.2000.03579.x.


Pseudoscleroderma as a paraneoplastic syndrome is a rare disease. We report here a patient with lung cancer (undifferentiated squamous cell carcinoma), who developed acrosclerosis. Using in situ hybridization, marked expression of alpha1(I)-collagen and connective tissue growth factor (CTGF) mRNA was found in fibroblasts scattered throughout the dermis. However, transforming growth factor (TGF)-beta1 expression was not detected. The pattern of CTGF gene expression and collagen synthesis was similar to that in systemic scleroderma. The absence of TGF-beta1 mRNA could indicate that tumour-derived factors induce the expression of CTGF.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell / complications*
  • Collagen / genetics
  • Connective Tissue Growth Factor
  • Female
  • Gene Expression
  • Growth Substances / genetics
  • Humans
  • Immediate-Early Proteins / genetics
  • Intercellular Signaling Peptides and Proteins*
  • Lung Neoplasms / complications*
  • Paraneoplastic Syndromes / etiology*
  • Paraneoplastic Syndromes / metabolism
  • Scleroderma, Systemic / etiology*
  • Scleroderma, Systemic / metabolism


  • CCN2 protein, human
  • Growth Substances
  • Immediate-Early Proteins
  • Intercellular Signaling Peptides and Proteins
  • Connective Tissue Growth Factor
  • Collagen