Solitary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis

Pathol Int. 2000 May;50(5):431-9. doi: 10.1046/j.1440-1827.2000.01055.x.


A rare case of recurrent respiratory papillomatosis (RRP) is reported with a review of the literature. A 40-year-old Japanese woman had suffered from RRP since 1 year of age. She developed a pulmonary squamous papilloma with a thin-walled cavity, which was suspected as being lung carcinoma. The trachea and bronchi around the tumor were intact, and no malignant transformation was present. Two types of human papillomavirus, 6 and 16, were detected, both in the laryngeal and pulmonary papillomas by in situ hybridization and the polymerase chain reaction method. To date, only 40 cases of juvenile laryngeal papilloma with pulmonary involvement have been reported in the English literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • DNA, Viral / analysis
  • Female
  • Humans
  • In Situ Hybridization
  • Laryngeal Neoplasms / pathology*
  • Laryngeal Neoplasms / virology
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / virology
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / virology
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / virology
  • Papilloma / pathology*
  • Papilloma / virology
  • Papillomaviridae / classification
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections
  • Polymerase Chain Reaction
  • Tumor Virus Infections


  • DNA, Viral