Internal dosimetry in the use of radiopharmaceuticals in therapy--science at a crossroads?

Cancer Biother Radiopharm. 1999 Apr;14(2):81-9. doi: 10.1089/cbr.1999.14.81.

Abstract

Because of expanding therapeutic applications, radionuclide dosimetry is in a stage of reference "man" based system to systems for "patient-specific dosimetry." Although the challenges for the latter system are substantial, patient-specific radiation dosimetry has greater relevance to treatment planning.

Publication types

  • Review

MeSH terms

  • Adult
  • Algorithms
  • Bone Marrow / radiation effects
  • Bone and Bones / radiation effects
  • Female
  • Genetic Variation
  • Humans
  • Immunoconjugates / analysis
  • Immunoconjugates / pharmacokinetics
  • Male
  • Models, Anatomic
  • Models, Biological
  • Organ Specificity
  • Radioimmunotherapy
  • Radiometry / methods*
  • Radiometry / standards
  • Radiopharmaceuticals / analysis*
  • Radiopharmaceuticals / pharmacokinetics
  • Radiotherapy Dosage*
  • Tissue Distribution

Substances

  • Immunoconjugates
  • Radiopharmaceuticals