Tumor cell growth suppression by tannic acid

Cancer Biother Radiopharm. 1999 Apr;14(2):135-8. doi: 10.1089/cbr.1999.14.135.

Abstract

Tannic acid was cultured together with tumor cells that had originated from human malignant tumors (HCT-15 & AGS). Significant suppression of tumor growth was observed. The 50% suppression was observed at the concentration between 50 micrograms/ml and 12.5 micrograms/ml. When tannic acid was injected into HCT-15 cells by electroporation at 1180 mu p and 200 ohm, the suppression rate was 34.3% at the concentration of 50 micrograms/ml in HBS solution. The suppression rate of cells only in contact with tannic acid solution for one hour under the same conditions as used for electroporation, was 26.1%. Histographic findings suggested that tannic acid almost completely blocked the S phase of the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / pathology*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacology*
  • Colonic Neoplasms / pathology*
  • DNA Replication / drug effects
  • DNA, Neoplasm / analysis
  • Drug Screening Assays, Antitumor
  • Electroporation
  • Humans
  • Hydrolyzable Tannins / administration & dosage
  • Hydrolyzable Tannins / pharmacology*
  • Nucleic Acid Synthesis Inhibitors / administration & dosage
  • Nucleic Acid Synthesis Inhibitors / pharmacology
  • Stomach Neoplasms / pathology*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • DNA, Neoplasm
  • Hydrolyzable Tannins
  • Nucleic Acid Synthesis Inhibitors