The SHORT-ROOT gene controls radial patterning of the Arabidopsis root through radial signaling

Cell. 2000 May 26;101(5):555-67. doi: 10.1016/s0092-8674(00)80865-x.


Asymmetric cell divisions play an important role in the establishment and propagation of the cellular pattern of plant tissues. The SHORT-ROOT (SHR) gene is required for the asymmetric cell division responsible for formation of ground tissue (endodermis and cortex) as well as specification of endodermis in the Arabidopsis root. We show that SHR encodes a putative transcription factor with homology to SCARECROW (SCR). From analyses of gene expression and cell identity in genetically stable and unstable alleles of shr, we conclude that SHR functions upstream of SCR and participates in a radial signaling pathway. Consistent with a regulatory role in radial patterning, ectopic expression of SHR results in supernumerary cell divisions and abnormal cell specification in the root meristem.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / genetics
  • Arabidopsis / growth & development*
  • Arabidopsis Proteins*
  • Base Sequence
  • Cell Differentiation
  • Cell Division
  • Cloning, Molecular
  • DNA Transposable Elements
  • DNA, Plant
  • Gene Expression
  • Gene Expression Regulation, Plant
  • Genes, Plant
  • Molecular Sequence Data
  • Plant Proteins / genetics*
  • Plant Roots / growth & development
  • Signal Transduction / physiology*
  • Transcription Factors / genetics*


  • Arabidopsis Proteins
  • DNA Transposable Elements
  • DNA, Plant
  • Plant Proteins
  • SCR protein, Arabidopsis
  • SHORT ROOT protein, Arabidopsis
  • Transcription Factors

Associated data

  • GENBANK/AF233752
  • GENBANK/AF233753