Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

Oncogene. 2000 May 15;19(21):2557-65. doi: 10.1038/sj.onc.1203524.


Cells of the immune system communicate with each other to initiate, establish and maintain immune responses. The communication occurs through cell-to-cell contact or through a variety of intercellular mediators that include cytokines, chemokines, growth factors and hormones. In the case of cytokines, the signal is transmitted from the outside to the inside of a cell through cell surface receptors specific for each cytokine. At this step the signal is also decoded and amplified: ligand binding causes recruitment and/or activation of numerous cytoplasmic proteins. One cytokine can activate a number of signal transduction pathways leading to regulation of a wide array of biological activities. One of these pathways, the Jak-Stat pathway, is briefly reviewed here with respect to the class II cytokine receptors. Signal transduction through receptors for interferons Type I (IFN-alpha, IFN-beta, IFN-omega) and Type II (IFN-gamma), and interleukin 10 (IL-10) is described in detail. In addition, a complex between tissue factor (TF) and coagulation factor VIIa, and two new receptors related to the class II cytokine receptor family are discussed. Oncogene (2000).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Janus Kinase 1
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Cytokine / chemistry
  • Receptors, Cytokine / metabolism*
  • Receptors, Interferon / chemistry
  • Receptors, Interferon / metabolism
  • Receptors, Interleukin / metabolism
  • Receptors, Interleukin-10
  • STAT1 Transcription Factor
  • Sequence Alignment
  • Signal Transduction*
  • Trans-Activators / metabolism*


  • DNA-Binding Proteins
  • Receptors, Cytokine
  • Receptors, Interferon
  • Receptors, Interleukin
  • Receptors, Interleukin-10
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • JAK1 protein, human
  • Janus Kinase 1