Roles of STAT3 defined by tissue-specific gene targeting

Oncogene. 2000 May 15;19(21):2607-11. doi: 10.1038/sj.onc.1203478.


The physiological role of each individual STAT protein is now being examined through the study of 'knockout' (KO) mice, harboring a null allele for the particular gene. In contrast to other STATs deficient mice that are born alive, STAT3-deficient mice die during early embryogenesis. However, the role of STAT3 in adult tissues can be assessed by utilizing the Cre-loxP recombination system to ablate the gene in later life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3 plays a crucial role in a variety of biological functions including cell growth, suppression and induction of apoptosis, and cell motility. Oncogene (2000).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • Base Sequence
  • Cells, Cultured
  • Cytokine Receptor gp130
  • DNA-Binding Proteins / deficiency*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Embryonic and Fetal Development / genetics
  • Gene Deletion*
  • Gene Targeting
  • Membrane Glycoproteins / metabolism
  • Mice
  • Mice, Knockout
  • Organ Specificity*
  • STAT3 Transcription Factor
  • Signal Transduction
  • Trans-Activators / deficiency*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*


  • Antigens, CD
  • DNA-Binding Proteins
  • Il6st protein, mouse
  • Membrane Glycoproteins
  • STAT3 Transcription Factor
  • Stat3 protein, mouse
  • Trans-Activators
  • Cytokine Receptor gp130