Molecular determinants of presynaptic active zones

Curr Opin Neurobiol. 2000 Jun;10(3):321-7. doi: 10.1016/s0959-4388(00)00093-3.


The presynaptic cytoskeletal matrix (cytomatrix) assembled at active zones has been implicated in defining neurotransmitter release sites. Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cytomatrix proteins. These multidomain proteins are thought to organize the exocytotic and endocytotic machinery precisely at active zones.

Publication types

  • Review

MeSH terms

  • Animals
  • Endocytosis / physiology
  • Exocytosis / physiology
  • Neurons / chemistry*
  • Neurons / metabolism*
  • Presynaptic Terminals / chemistry*
  • Presynaptic Terminals / metabolism*