Control of cell behaviour by signalling through Eph receptors and ephrins

Curr Opin Neurobiol. 2000 Jun;10(3):400-8. doi: 10.1016/s0959-4388(00)00095-7.


Eph receptor tyrosine kinases and ephrins mediate contact-dependent cell interactions that regulate the repulsion and adhesion mechanisms involved in the guidance and assembly of cells. Recent work has revealed a role of overlapping Eph receptor and ephrin expression in modulating neuronal growth cone repulsion, and has shown that bidirectional activation restricts intermingling and communication between cell populations. In addition, progress has been made in understanding how Eph receptors and ephrins control cell adhesion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Ephrin-A1
  • Ephrin-B1
  • Membrane Proteins / physiology
  • Neurons / physiology*
  • Proteins / physiology*
  • Receptor Protein-Tyrosine Kinases / physiology*
  • Receptor, EphB4
  • Receptors, Eph Family
  • Signal Transduction / physiology*


  • Ephrin-A1
  • Ephrin-B1
  • Membrane Proteins
  • Proteins
  • Receptor Protein-Tyrosine Kinases
  • Receptor, EphB4
  • Receptors, Eph Family