Downregulation of G protein-coupled receptors

Curr Opin Neurobiol. 2000 Jun;10(3):365-9. doi: 10.1016/s0959-4388(00)00096-9.


Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, has been examined in detail. Specific protein interactions that control the specificity of G-protein-coupled receptor trafficking in this pathway are beginning to be elucidated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Down-Regulation / physiology*
  • Endocytosis / physiology*
  • GTP-Binding Proteins / metabolism*
  • Neurons / physiology*
  • Receptors, Cell Surface / metabolism*


  • Receptors, Cell Surface
  • GTP-Binding Proteins