Homer: a link between neural activity and glutamate receptor function

Curr Opin Neurobiol. 2000 Jun;10(3):370-4. doi: 10.1016/s0959-4388(00)00087-8.


The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / physiology*
  • Homer Scaffolding Proteins
  • Humans
  • Neurons / physiology*
  • Neuropeptides / physiology*
  • Receptors, Glutamate / physiology*
  • Synaptic Transmission / physiology*


  • Carrier Proteins
  • Homer Scaffolding Proteins
  • Neuropeptides
  • Receptors, Glutamate