Single-molecule studies of DNA mechanics

Curr Opin Struct Biol. 2000 Jun;10(3):279-85. doi: 10.1016/s0959-440x(00)00085-3.


During the past decade, physical techniques such as optical tweezers and atomic force microscopy were used to study the mechanical properties of DNA at the single-molecule level. Knowledge of DNA's stretching and twisting properties now permits these single-molecule techniques to be used in the study of biological processes such as DNA replication and transcription.

MeSH terms

  • Animals
  • DNA / chemistry*
  • Elasticity
  • Humans
  • Nucleic Acid Conformation*


  • DNA