Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol

Antonie Van Leeuwenhoek. 1976;42(1-2):9-12. doi: 10.1007/BF00399444.


The minimum inhibiting concentrations (MIC) of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1-5 mug/ml. In the same range, both compounds are also bactericidal. In media containing 4% serum or 5% blood the antibacterial activity is strongly reduced (MIC 50 mug/ml). Gram-negative bacteria are resistant to THC and CBD.

MeSH terms

  • Cannabidiol / pharmacology*
  • Cannabis / pharmacology*
  • Cell Division / drug effects
  • Dronabinol / pharmacology*
  • Enterobacteriaceae / drug effects
  • Species Specificity
  • Staphylococcus / drug effects*
  • Streptococcus / drug effects*


  • Cannabidiol
  • Dronabinol